If you have taken promethazine for a long time and suddenly stop taking it, it's possible you might feel dizzy, sweaty or sick, have a racing heart and have trouble sleeping. Speak to your doctor if you have taken promethazine for a long time and want to stop taking it. Promethazine is known as a drowsy sedating antihistamine as it makes you sleepy.
Non-drowsy antihistamines are less likely to have this effect. These include cetirizine , fexofenadine and loratadine. Most people prefer to take a non-drowsy antihistamine as it's less likely to interfere with their everyday routine.
You might choose to take a drowsy antihistamine, however, if you're having problems falling asleep, or if symptoms like itching or coughing are keeping you awake.
There is not enough information available to say whether one antihistamine is better than another for treating allergies. You may need to try a few different medicines to find what works best for you. Ask your pharmacist or doctor for advice if you're unsure.
You can take 2 different antihistamines at a time, if your doctor says it's OK. If you have a severe itchy skin rash, your doctor may recommend 2 different antihistamines together for a few days.
You could take a non-drowsy antihistamine such as cetirizine , fexofenadine or loratadine during the day, and a drowsy antihistamine at night if itching is making it difficult to sleep. Do not take another drowsy antihistamine together with promethazine. It'll make you very tired and sleepy. Other drowsy antihistamines include chlorphenamine Piriton and diphenhydramine Nytol Original.
Do not take 2 antihistamines together unless you have been advised to by your doctor. If you take it for insomnia or take it at bedtime, promethazine will help you sleep. If you take it during the day for other conditions, such as allergies, it might make you feel sleepy during the day as well. Yes, you can take promethazine together with some painkillers, such as paracetamol or ibuprofen.
If you take promethazine with painkillers that contain codeine such as co-codamol or other prescription painkillers , you may feel very tired and sleepy. It's important to check the packaging or label of your medicine carefully. This is because some promethazine products already contain a painkiller. Do not take extra painkillers if this is the case, as there's a risk of overdose.
Speak to your pharmacist if you're not sure whether a medicine already contains a painkiller. Do not drive a car or ride a bike if promethazine makes you sleepy during the daytime, gives you blurred vision or makes you feel dizzy, clumsy or unable to concentrate or make decisions.
This may be more likely when you first start taking promethazine, but could happen at any time for example, when starting another medicine. It's an offence to drive a car if your ability to drive safely is affected. It's your responsibility to decide if it's safe to drive.
If you're in any doubt, do not drive. Talk to your doctor or pharmacist if you're unsure whether it's safe for you to drive while taking promethazine. UK has more information on the law on drugs and driving. There's no evidence to suggest that taking promethazine reduces fertility in either men or women. But speak to a pharmacist or doctor before taking it if you're trying to get pregnant.
Promethazine does not affect any type of contraception, including the combined pill and emergency contraception. You will not be able to breathe properly and may have difficulty waking up.
However, do not drink alcohol. And if you take promethazine to help you sleep, try not to have drinks that contain caffeine, like coffee, tea, cola or energy drinks. Caffeine has the opposite effect to promethazine and can stop the medicine working. Yes, it's dangerous to take promethazine with recreational drugs. This is because it can slow or stop your heart and lungs. Mixing promethazine and codeine in large amounts slows down the central nervous system brain and spinal cord , which can slow breathing and heart rate.
It's even more dangerous when taken with alcohol or other drugs and has caused people to die. Find out more the side effects of some recreational drugs on the Frank website. Promethazine will only help you sleep while you're taking it, so there are a number of things you can do instead to help yourself have a good night's sleep :.
If you have hay fever , it helps if you do not spend too much time outside if the pollen count is high. The best way to prevent any sort of allergic reaction is to avoid the substance that you're allergic to, if you can. There are some practical steps you can follow to help prevent allergies. Page last reviewed: 27 October Next review due: 27 October Promethazine Phenergan - Other brand names: Avomine, Sominex On this page About promethazine Key facts Who can and cannot take promethazine How and when to take promethazine Side effects How to cope with side effects of promethazine Pregnancy and breastfeeding Cautions with other medicines Common questions about promethazine.
About promethazine Promethazine is an antihistamine medicine that relieves the symptoms of allergies. Promethazine is used for: short-term sleep problems insomnia — including when a cough, cold or itching is keeping you awake at night allergies, including hay fever and hives urticaria feeling and being sick vomiting — due to motion sickness or vertigo cold symptoms, such as coughing and a runny nose You can buy promethazine from pharmacies, where it's often sold as Avomine, Phenergan or Sominex.
It comes as tablets, capsules and a liquid that you swallow. Help us improve our website Can you answer a quick question about your visit today? When promethazine is used to treat or prevent nausea and vomiting it is usually taken every 4 to 6 hours as needed. Promethazine may also be taken at bedtime the night before surgery to relieve anxiety and produce quiet sleep. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.
Take promethazine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Promethazine suppositories are for rectal use only. Do not try to swallow the suppositories or insert in any other part of your body. If you are taking promethazine liquid, do not use a household spoon to measure your dose. Use the measuring spoon or cup that came with the medication or use a spoon made especially for measuring medication. This medication may be prescribed for other uses; ask your doctor or pharmacist for more information. Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule.
Do not take a double dose to make up for a missed one. Promethazine may cause other side effects. Call your doctor if you experience any unusual problems while you are taking this medication. Keep this medication in the carton or container it came in, tightly closed, and out of reach of children.
Store promethazine tablets and liquid at room temperature and away from excess heat and moisture not in the bathroom. Store promethazine suppositories in the refrigerator. Protect the medication from light. Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. It is important to keep all medication out of sight and reach of children as many containers such as weekly pill minders and those for eye drops, creams, patches, and inhalers are not child-resistant and young children can open them easily.
To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location — one that is up and away and out of their sight and reach. Serious side effects and their symptoms can include the following:. Disclaimer: Our goal is to provide you with the most relevant and current information.
However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice.
Always discuss possible side effects with a healthcare provider who knows your medical history. Promethazine oral tablet can interact with other medications, vitamins , or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.
To help avoid interactions, your doctor should manage all of your medications carefully. When you take certain allergy drugs with promethazine, you may have increased side effects. These can include dry mouth , constipation , trouble emptying your bladder, blurred vision, and drowsiness. Examples of these drugs include:. If you take certain antidepressant drugs called monoamine oxidase inhibitors MAOIs with promethazine, you raise your risk of extrapyramidal symptoms.
These symptoms include uncontrollable upward staring, eye and lid twitching, uncontrollable neck muscle contractions causing your head to twist or turn to one side , and sticking out your tongue uncontrollably. Promethazine can cause severe drowsiness.
When you take drugs called tricyclic antidepressants with promethazine, you may have drowsiness that is more extreme and lasts longer. When you take certain anxiety drugs with promethazine, you may have drowsiness that is more extreme and lasts longer.
When you take certain bladder control drugs with promethazine, certain side effects may increase and last longer.
These side effects include dry mouth, constipation, trouble emptying your bladder, blurred vision, and drowsiness. When you take certain muscle relaxants with promethazine, you may have drowsiness that is more extreme and lasts longer.
When you take certain nausea and motion sickness drugs with promethazine, certain side effects may increase and last longer. When you take certain pain drugs with promethazine, you may have drowsiness that is more extreme and lasts longer. When you take certain stomach and gastrointestinal drugs with promethazine, certain side effects may increase and last longer. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions.
Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking. Taking it again could be fatal cause death. Drinking alcohol can make drowsiness from promethazine more extreme and last longer. For people with angle-closure glaucoma : Angle-closure glaucoma leads to increased pressure in your eyes.
If you have a history of angle-closure glaucoma, taking this drug may cause a sudden and severe increase in eye pressure. This is an emergency and may result in irreversible vision loss. Talk to your doctor before using this drug if you have this condition.
For people with enlarged prostate: If you have trouble urinating due to an enlarged prostate gland, taking this drug may make it even more difficult for you to urinate. For people with certain stomach problems: If you have a history of digestive tract blockage, taking this drug may make blockage worse. This is because this drug slows down movement through your digestive tract. For people with certain bladder problems: If you have a blockage in your bladder, taking this drug may make it more difficult for you to urinate.
It can be difficult to know what these products actually contain and the potential effects these substances may have. Always talk to your doctor before using such products, since even herbal ingredients can lead to potentially serious interactions and side effects.
Codeine is a habit-forming opioid pain reliever, which means taking more than prescribed can easily lead to dependence and potentially addiction. How long promethazine with codeine cough syrup will remain in your body depends on several factors, including dosage, how often you use the medication, your age, weight, and metabolism, as well as your hydration and activity levels.
While there is no exact drug test or timeline for purple drank, here is an estimated detection window for codeine according to drug test type:.
Developing an addiction to purple drank is possible—but it won't happen overnight. Factors like genetics, environment, underlying mental health as well as the frequency of use all play a role in whether or not someone develops an addiction.
Withdrawal from purple drank use can be very uncomfortable, but it is not life-threatening. Although complications can occur that pose a potential danger. For example, vomiting and diarrhea can cause dehydration as well as chemical and mineral disturbances in your body. Overdose is also possible if you quit and then take the same dose of the drug again. Your body will no longer be able to tolerate the amount you used to take. If you or a loved one is misusing cough syrup, please seek help and consult with a primary care physician, nurse practitioner, or mental health professional who can refer you to an addiction specialist.
For more mental health resources, see our National Helpline Database. You may need long-term recovery support or addiction treatment following withdrawal to stay off this drug cocktail, including:. Remember: There's no shame in getting help; it's one of the bravest things you can do. Learn the best ways to manage stress and negativity in your life.
Purple drank prevalence and characteristics of misusers of codeine cough syrup mixtures. Addict Behav. Representations of codeine misuse on Instagram: Content analysis. University of Michigan. Monitoring the Future. National Institute of Drug Abuse.
Hallucinogens and Dissociative Drugs. Library of Medicine.
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